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Mulethi Dry Extract |
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Botanical Name |
Glysyrrhiza Glabra |
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Active Ingredients |
20.0% Glysyrrzine |
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Pharmacological Action |
Expectorent, Anti-Infective, Anti Ulcer |
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Licorice is something every cild seems to develop a fondness for due to the fact
that it is roughly 50 times sweeter than sugar. But in fact, they are providing
many health benefits at the same time particularly for the adrenal glands. This
herb has long been valued as a semulcent (soothing, coating agent) and continues
to be used by professional herbalists today to relieve respiratory ailments (such
as allergies, bronchitis, colds, sore throats, and tuberculosis), sotmach problems
(including, possibly, heartburn form reflux or some other cause and gastritis),
infimmatory disorders, skin deseases, and liver problems. Licorice root is often
used to prevent and treat stomach ulcers. Early studies in humans have found that
preparations containing glycyrrhizin (an active compound in licorice) may be as
effective as leading anti-ulcer medications in releaving pain associated with stomach
ulcers and preventing the ulcers from recurring. Active compounds in licorice root
are also used to help prevent and treat chronic hepatitis (liver inflammation).
Licorice also plays a role in the treatment of heart disease because of its effects
on cholestrole and blood pressure. Preliminary studies also suggest that licorice
may play a role in the treatment of human immunodeficiency virus (HIV) and Japanese
encephalitis. One early study of only 3 people with HIV suggested that intravenous
glysyrrhizin may prevent replication of HIV, but larger studies have yet to duplicate
these findings.
Extensive reports are availbale on modern pharmacological research on this drug
supporting its claim in the oerder literature as a broad spectrum entity in many
pharmacopoeia. Recent studies report the anti-inflammatory action of glycyrrhetinic
acid a hydrolysis product of glycyrrhizin and its derivative in the rat paw and
cotton-pallet test. Both liquorice extract and glycyrrhetinnic acid are shown
to have desoxycorticosterone, and ACTH-like effects, though with less toxicity than
cartisone, encouraging its use as an antiarthritic agent, in Addison's disease and
simmond's disease. Deglycyrrhiznised liquorice is used in peptic ulcer. Glycyrrhizine
(L II) and glycyrhetic acid (L III) prevented the development of experimental cirrhosis
in rats. Triglycerides accumulation in the liver decreased, while liver glycogen
increased signifiacntly in rats treated with L III. Effects of L II and its congreners
have been studied on free radical generation and lipid peroxidation in primary cultured
rat hepatocytes. Antioxidative action plays an important role int he antihepatotxic
activity of L III. The effectiveness of II-deoxy-glycurrhetinic acid hydrogen maleate
(LIV) against liver damage induced by carbon tetrachloride has also been demonstrated.
In ayurveda, it i used extensively as a demulcent, mild expectorant and anti-inflammatory
agent. It relieves 'vata' and 'kapha' inflammations, it is used in eye diseases,
throat infections, symptomatic relief in peptic ulcer, and as an antiarthritic agent.
One hundres and thirty-three cases of chronic liver diseases treated with L II,
daily for one month, showed significant improvement. Marked improvement in serum
transaminase levels was seen after one week, without any side effects.
Glycyrrhizic acid has been reported to cause oedema.
Its effect is less toxic than that of cortisone. Large doses of liquorice (30-50
gms) can produce Cushingoid features in man. |
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